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ES Notes July 2009
In this summer issue of ES Notes we would like to share with you some of the new products we have introduced recently including information on HILIC Chromatography, acidic and basic compound separation by SFC and selectivity and materials and columns for Rapid Separations and UPLC - all designed to be technically informative and practically useful.
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Polar Compounds separated by HILIC HPLC
versed-phase HPLC is widely used for separation of many pharmaceutical compounds. However, retention and separation of many polar analytes has proven to be a challenge. Many of these types of compounds are unretained or poorly retained on most conventional reversed-phase stationary phases, such as ODS. Fortunately, to deal with these types of analytes an alternative mode of chromatography can be utilized using polar stationary phases and highly organic mobile phases. This mode of chromatography has been utilized for many years and is referred to as "hydrophilic interaction chromatography" or HILIC. HILIC chromatography uses mobile phases containing between 5 - 20 % water for the retention of polar compounds.
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 Rapid Separation and UPLC materials
ES Industries is pleased to introduce a full line of Epic 1.8um columns for use with ultra high pressure liquid chromatographs. These columns have been engineered to specifically for chromatography at pressures up to 15000 psi. ES Industries expertise in the silica surface modification and bond stationary technology has enabled us to develop a number of stationary phases based on the 1.8um particle technology. With this breakthrough the chromatographer is not limited to ODS type phases.
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Acidic and Basic compound separations bySFC
Many SFC separations have been forced to utilize older types of stationary phases from "normal phase" HPLC such as unmodified silica, diol, amino and cyano. These phases are poorly adapted to SFC and present a number of limitations for SFC separations. Limitations include: low capacity, poor selectivity, and poor peak shape for SFC separations. Chromegabond Pyridyl Amide
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P.S. Watch next month for technical information on a new line of fluorinated phases; the Epic LB (low bleed) series. Epic Polar HPLC Columns and Ethyl Pyridine material providing superior selectivity for difficult SFC separations.
David Kohler
President
ES Industries, Inc.
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